By train:
From Milan (southbound) or Rome (northbound) stop at Chiusi Chianciano Terme and then take the local train to Montepulciano.

By car:
"Autostrada del Sole" (A1) Milan-Naples. Driving from Milan (southbound), exit at Valdichiana and then follow the road sign to Moltepulciano.
Driving from Rome (northbound), exit at Chiusi C.T., follow the road sign to Chianciano and then to Montepulciano.

By plane:
The nearest airports are those of Florence( 125 km) , Pisa( 190 km), and Roma (200 km).

Distances in Km:
Perugia 73, Arezzo 62, Siena 65, Firenze 120, Orvieto 55, Roma 180
ed inoltre Chiusi 24, Pienza 10, Cortona 32, Montalcino 30, Assisi. 95.